![]() ![]() subtilis strain WS-1 acts as a potential biocontrol agent protecting pigs from pathogenic E. Collectively, these findings suggest that the probiotic B. Furthermore, histopathological results showed that the WS-1 strain could protect small intestine from lesions caused by E. subtilis strain WS-1 by oral feeding was able to clearly inhibit diarrhea ( p < 0.05) and death ( p < 0.05) caused by pathogenic E. ![]() Importantly, inoculation of newborn piglets with 1.5 × 10 10 CFU of B. subtilis strain WS-1 shares 100% genomic synteny with B. subtilis strain WS-1 showed typical Bacillus characteristics by endospore staining, biochemical test, enzyme activity analysis, and 16S rRNA sequence analysis. WS-1 can strongly inhibit the growth of pathogenic E. subtilis, named WS-1, from apparently healthy pigs growing with sick cohorts on one Escherichia coli endemic commercial pig farm in Guangdong, China. In this study, we isolated one strain of B. Additionally, it has great potential to be used as an alternative to antimicrobial drugs, which is significant in the context of antibiotic abuse in food animal production.
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